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For US Residents Healthcare Professionals
Full Safety Information Full Prescribing Information Healthcare Professionals

The mysteries of

menopause solved

Feeling like a hot mess?
Here’s why.

Your body naturally produces a family of hormones called estrogen—you’ve probably heard of it1,2

Estradiol (E2) is the main and most potent type of estrogen. It plays an important role in regulating the menstrual cycle, reproduction, bone health, and cardiovascular health.3-6
As you transition into menopause, your estradiol levels drop, and that can result in some pretty uncomfortable side effects, like1,3,7:
Menstrual changes
Bladder issues
Vaginal dryness
Mood changes
Hot flashes
Brain fog
Joint pain

We’d list them all, but seriously—there’s not enough room.
There are dozens of recognized symptoms of menopause.8

One of the most common symptoms of menopause is hot flashes1
The fancy medical term is vasomotor symptoms, or VMS for short, and includes hot flashes during the day, as well as night sweats. The majority of women experience VMS, and one-third to half of those women experience moderate to severe symptoms. It can be seriously disruptive to sleep and daily life.9-11

In one study, women were interviewed about the ways VMS impacted their quality of life.11,*
mentioned that hot flashes and night sweats negatively impacted their sleep
reported that VMS impacted their emotions/mood, describing feelings of irritation, discomfort, and embarrassment
reported that VMS negatively affected their relationships with spouses, loved ones, or coworkers

Another study assessed the effect of VMS on women's work life.12,†

reported that VMS symptoms negatively impacted their performance at work12

*In-person interviews were conducted for a total of 16 women in the United States aged 40 to 64 years who were experiencing ≥35 moderate to severe hot flashes and/or night sweats per week.11

†Questionnaires were collected from 407 women, of whom 339 were aged 45 to 64 years and were experiencing menopause symptoms or had already gone through menopause. Participants rated the extent to which 10 menopause symptoms affected their work.12

Menopause treatments—a hot topic, and a confusing one

As if menopause symptoms weren’t enough, the treatment landscape can be equally overwhelming, filled with buzzwords and contradictions. We’re here to help you make sense of it all.13
Actor portrayals.
Actor portrayals.

MHT: Let’s talk about it

Menopause hormone therapy, or MHT, sounds a lot like what it is: the use of hormones to treat menopause symptoms. MHT helps relieve symptoms associated with menopause by replacing hormones.3

MHT is the first choice of many experts to treat menopause symptoms like VMS. In 2026, the FDA announced that MHTs like BIJUVA® are a valuable choice for women who are younger than 60 years old or who entered menopause within the past 
10 years.14,15

Are you looking for proven relief from VMS with a well-documented safety profile and the simplicity of a once-daily capsule?16

Explore BIJUVA

References: 1. Crandall CJ, Mehta JM, Manson JE. Management of menopausal symptoms: a review. JAMA. 2023;329(5):405-420. 2. Panay N, Ang SB, Cheshire R, Goldstein SR, Maki P, Nappi RE; International Menopause Society Board. Menopause and MHT in 2024: addressing the key controversies – an International Menopause Society White Paper. Climacteric. 2024;27(5):441-457. 3. Stute P, Marsden J, Salih N, Cagnacci A. Reappraising 21 years of the WHI study: putting the findings in context for clinical practice. Maturitas. 2023;174:8-13. 4. Zhu J, Zhou Y, Jin B, Shu J. Role of estrogen in the regulation of central and peripheral energy homeostasis: from a menopausal perspective. Ther Adv Endocrinol Metab. 2023;14:20420188231199359. 5. Aryan L, Younessi D, Zargari M, et al. The role of estrogen receptors in cardiovascular disease. Int J Mol Sci. 2020;21(12):4314. 6. Chen P, Li B, Ou-Yang L. Role of estrogen receptors in health and disease. Front Endocrinol (Lausanne). 2022;13:839005. 7. Maki PM, Jaff NG. Brain fog in menopause: a health-care professional’s guide for decision-making and counseling on cognition. Climacteric. 2022;25(6):570-578. 8. Aras SG, Grant AD, Konhilas JP. Clustering of > 145,000 symptom logs reveals distinct pre, peri, and menopausal phenotypes. Sci Rep. 2025;15(1):640. 9. Wright AC, Beaudoin FL, McQueen RB, et al. The effectiveness and value of fezolinetant for moderate-to-severe vasomotor symptoms associated with menopause: a summary from the Institute for Clinical and Economic Review’s Midwest Public Advisory Council. J Manag Care Spec Pharm. 2023;29(6):692-698. 10. Mirkin S, Graham S, Revicki DA, Bender RH, Bernick B, Constantine GD. Relationship between vasomotor symptom improvements and quality of life and sleep outcomes in menopausal women treated with oral, combined 17β-estradiol/progesterone. Menopause. 2019;26(6):637-642. 11. English M, Stoykova B, Slota C, et al. Qualitative study: burden of menopause-associated vasomotor symptoms (VMS) and validation of PROMIS Sleep Disturbance and Sleep-Related Impairment measures for assessment of VMS impact on sleep. J Patient Rep Outcomes. 2021;5(1):37. 12. O’Neill MT, Jones V, Reid A. Impact of menopausal symptoms on work and careers: a cross-sectional study. Occup Med (Lond). 2023;73(6):332-338. 13. Panay N, Fenton A, Hamoda H, et al; IMS Recommendations Writing Group. International Menopause Society (IMS) recommendations and key messages on women’s midlife health and menopause. Climacteric. 2025;28(6):634-656. 14. North American Menopause Society Advisory Panel. The 2022 hormone therapy position statement of The North American Menopause Society. Menopause. 2022;29(7):767-794. 15. FDA approves labeling changes to menopausal hormone therapy products. News release. US Food and Drug Administration. February 12, 2026. Accessed July 14, 2026. https://www.fda.gov/news-events/press-announcements/fda-approves-labeling-changes-menopausal-hormone-therapy-products 16. BIJUVA [package insert]. Raleigh, NC: Mayne Pharma. February 2026.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about BIJUVA® (a combination of estrogen and progestogen)?
  • Do not use estrogens with or without progestogens to prevent heart disease, heart attacks, strokes, or dementia (decline in brain function).
  • Using estrogens with progestogens may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots.
Who should not use BIJUVA?

Do not use BIJUVA if you have had your uterus (womb) removed (hysterectomy). BIJUVA contains a progestogen to decrease the chance of getting cancer of the uterus. If you do not have a uterus, you do not need a progestogen and you should not use BIJUVA.

Do not start using BIJUVA if you:
  • Have unusual vaginal bleeding. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause.
  • Have been diagnosed with a bleeding disorder.
  • Currently have or have had certain cancers. Estrogens may increase the chances of getting certain types of cancers, including cancer of the breast or uterus (womb). If you have or have had cancer, talk to your healthcare provider about whether you should use BIJUVA.
  • Currently have or have had blood clots.
  • Had a stroke or heart attack.
  • Currently have or have had liver problems.
  • Are allergic to BIJUVA or any of its ingredients.
Before you use BIJUVA, tell your healthcare provider about all of your medical conditions, including if you:
  • Have high levels of fat in your blood (triglycerides).
  • Have any unusual vaginal bleeding. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb).
  • Have any other medical conditions that may become worse while you are using BIJUVA.
  • Are going to have surgery or will be on bed rest. Your healthcare provider will let you know if you need to stop using BIJUVA.
  • Are pregnant or think you may be pregnant.
  • Are breastfeeding.

Tell your healthcare provider about all the medicines you take, including prescription and over the-counter medicines, vitamins, and herbal supplements. Some medicines may affect how BIJUVA works. BIJUVA may affect how your other medicines work. Keep a list of your medicines and show it to your healthcare provider and pharmacist when you get new medicine.

What are the possible side effects of BIJUVA?

Serious but less common side effects include:

  • heart attack
  • stroke
  • blood clots
  • breast cancer
  • cancer of the lining of the uterus (womb)
  • cancer of the ovary
  • dementia
  • gallbladder disease
  • high or low blood calcium levels
  • changes in vision
  • high blood pressure
  • high levels of fat in your blood (triglycerides)
  • liver problems
  • changes in thyroid hormone levels
  • swelling or fluid retention
  • cancer changes of endometriosis
  • enlargement of benign tumors of the uterus (“fibroids”)
  • worsening swelling of face or tongue (angioedema) in women who have a history of angioedema
  • changes in laboratory test results such as bleeding time and high blood sugar levels

Call your healthcare provider right away if you get any of the following warning signs or any other unusual symptoms that concern you:

  • new breast lumps
  • unusual vaginal bleeding
  • changes in vision or speech
  • sudden new severe headaches
  • severe pains in your chest or legs with or without shortness of breath, weakness and fatigue
  • vomiting

Common side effects of BIJUVA include:

  • breast tenderness
  • headache
  • nausea
  • vaginal bleeding
  • vaginal discharge
  • pelvic pain

Tell your healthcare provider if you have any side effects that bother you or do not go away. These are not all of the possible side effects of BIJUVA. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or Mayne Pharma at 1-844-825-8500.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about BIJUVA® (a combination of estrogen and progestogen)?
  • Do not use estrogens with or without progestogens to prevent heart disease, heart attacks, strokes, or dementia (decline in brain function).
  • Using estrogens with progestogens may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots.
Who should not use BIJUVA?

Do not use BIJUVA if you have had your uterus (womb) removed (hysterectomy). BIJUVA contains a progestogen to decrease the chance of getting cancer of the uterus. If you do not have a uterus, you do not need a progestogen and you should not use BIJUVA.